Chris Del Mar, the author of the article,
comments:
A Cochrane review of four randomised trials and
1943 patients indicates that intranasal steroids at
high doses do provide some relief of acute
sinusitis, although only for mild disease, and with
a number needed to treat of about 12.
1 Another Cochrane
review of five randomised trials with a total of
1193 adults found no benefit for systemic steroids
in acute sinusitis.
2
A third Cochrane review of acute respiratory
infections included 749 children and adults in five
randomised controlled trials. Participants were
randomised to saline nasal washouts or not. The
trials had such mixed results (heterogeneity) that
they could not be pooled, and were sufficiently
vulnerable to bias that any benefits were deemed
unreliable.
3
Combinations of these interventions have not been
studied in Cochrane reviews.