Dr Peter Collignon and Dr Robert Horvath, the authors of the article, comment:
The guidelines of the Centers for Disease Control (CDC) do recommend changes of peripheral lines after 72-96 hours rather than our suggested 48-72 hours. Our concern is that the CDC based the guidelines on the incidence of 'phlebitis', not bacteraemia. As phlebitis is thought to be usually due to non-infective causes (e.g. irritation from drugs), we do not believe it is an appropriate surrogate marker for bacteraemia.
If one examines bacteraemia caused by catheters, it becomes clear that there are almost no cases with catheters that are in place for 24 hours or less and sepsis is very uncommon if the catheters are in place for less than 48 hours.2,3,4The CDC guidelines still recommend routine replacement at 48 hours for 'emergency cannulas'. This is a vague definition and appears to take in our concerns.
In our experience children do not have peripheral cannulas for prolonged periods. Although there is no reason to believe that intravenous catheter sepsis will be different in children, we are unaware of any authority currently recommending routine replacement of peripheral catheters in children.
The problem with doing studies on peripheral catheter sepsis is the very low incidence of bacteraemia (about one episode for every 3000 catheters).5A prospective randomised study would have to be extremely large and is therefore unlikely to be done. However, we believe that the evidence on bacteraemia (rather than phlebitis) strongly suggests that routine replacement of catheters at 48-72 hours will result in lower sepsis rates than replacement at later times.