Recent coronial inquiries into 2 deaths have highlighted the need for health professionals to be alert to the well documented risk of overdose with baclofen.

This risk relates to intentional and unintentional overdose and is particularly pronounced when baclofen is used off label at higher doses for alcohol-use disorder. Close supervision of patients being treated with baclofen who have depression or a history of previous suicide attempts is recommended.

Warnings about this safety issue have been included in the prescribing information for baclofen since 2019.

See the full article on the TGA website. 

Reproduced with permission from Therapeutic Goods Administration (TGA) Medicines Safety Update 19 October 2023.