Summary
Recent coronial inquiries into 2 deaths have
highlighted the need for health professionals to be alert to the well
documented risk of overdose with baclofen.
This risk relates to intentional and unintentional overdose and
is particularly pronounced when baclofen is used off label at higher doses for
alcohol-use disorder. Close supervision of patients being treated with baclofen
who have depression or a history of previous
suicide attempts is recommended.
Warnings about this safety issue have been
included in the prescribing information for baclofen since 2019.
See the full article on the TGA website.
Reproduced
with permission from Therapeutic Goods Administration (TGA) Medicines Safety
Update 19 October 2023.
